Controllable Lewis Base Catalyzed Michael Addition of α-Amino­nitriles to Activated Alkenes: Facile Synthesis of Functionalized γ-Amino Acid Esters and γ-Lactams

Abstract

A novel protocol for the synthesis of functionalized γ-amino acid esters and γ-lactams through a controllable Lewis base catalyzed Michael addition of α-aminonitriles to simple activated alkenes has been developed. The scope, versatility, and efficiency of the process were demonstrated.

Key words

Lewis base - catalysis - Michael addition - α-amino nitriles - γ-amino acid derivatives

Publikationsverlauf

Eingereicht: 26. November 2020

Angenommen nach Revision: 15. Dezember 2020

Accepted Manuscript online:
15. Dezember 2020

Artikel online veröffentlicht:
12. Januar 2021

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