Controllable Lewis Base Catalyzed Michael Addition of α-Amino­nitriles to Activated Alkenes: Facile Synthesis of Functionalized γ-Amino Acid Esters and γ-Lactams

Ze-Ying He; Ho-Chol Jang; Le-Sheng Teng; Zhong-Lin Wei; Wei-Wei Liao

doi:10.1055/a-1337-4684

Synthesis, Table of Contents

Synthesis 2021; 53(10): 1833-1841
DOI: 10.1055/a-1337-4684

paper

Controllable Lewis Base Catalyzed Michael Addition of α-Aminonitriles to Activated Alkenes: Facile Synthesis of Functionalized γ-Amino Acid Esters and γ-Lactams

Authors

Ze-Ying He

^aDepartment of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. of China

^bZhuhai College of Jilin University, Jilin University, Zhuhai 519041, P. R. of China
Ho-Chol Jang

^aDepartment of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. of China
Le-Sheng Teng

^cCollege of Life Sciences, Jilin University, Changchun 130012, P. R. of China
Zhong-Lin Wei∗

^aDepartment of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. of China
Wei-Wei Liao∗

^aDepartment of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. of China

Abstract

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Abstract

A novel protocol for the synthesis of functionalized γ-amino acid esters and γ-lactams through a controllable Lewis base catalyzed Michael addition of α-aminonitriles to simple activated alkenes has been developed. The scope, versatility, and efficiency of the process were demonstrated.

Key words

Lewis base - catalysis - Michael addition - α-amino nitriles - γ-amino acid derivatives

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References

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Controllable Lewis Base Catalyzed Michael Addition of α-Amino­nitriles to Activated Alkenes: Facile Synthesis of Functionalized γ-Amino Acid Esters and γ-Lactams

Authors

Controllable Lewis Base Catalyzed Michael Addition of α-Aminonitriles to Activated Alkenes: Facile Synthesis of Functionalized γ-Amino Acid Esters and γ-Lactams