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DOI: 10.1055/a-1404-2763
Alkyl Halides as Substrates for Photocatalytic Minisci-Type C–H Alkylation of Hetarenes
We gratefully acknowledge funding from the National Science Centre, Poland (SONATA 2018/31/D/ST5/00306) for the financial support.
Dedicated to Professor Daniel Gryko on the occasion of his 50th birthday
Abstract
Alkyl halides are readily available starting materials for various synthetic transformations, including Minisci-type C–H functionalizations of hetarenes. The existing methods, however, often require harsh reaction conditions, such as the use of acids, sacrificial electron donors, or radical precursors in excess amounts. Here, we outline recent developments in this field and we highlight our group̓s efforts to achieve fully catalytic photoredox Minisci-type alkylations supported by noncovalent interactions under mild aqueous conditions.
Key words
C–H functionalization - Minisci reaction - alkyl bromides - hetarenes - photoredox catalysis - alkylationPublication History
Received: 11 February 2021
Accepted after revision: 02 March 2021
Accepted Manuscript online:
02 March 2021
Article published online:
16 March 2021
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