Synlett 2021; 32(13): 1309-1315
DOI: 10.1055/a-1409-2734
cluster account
Perspectives on Organoheteroatom and Organometallic Chemistry

Strategies of In Situ Generated Magnesium Catalysis in Asymmetric Reactions

Linqing Wang
,
Dongxu Yang
We acknowledge financial support from the National Natural Science Foundation of China (NSFC; 21901092), the Innovation fund for medical sciences (2019-12M-5-074), the Funds for Fundamental Research Creative Groups of Gansu Province (20JR5RA310), and the Fundamental Research Funds for the Central Universities (lzujbky-2020-49).


Abstract

Magnesium (Mg) is a cheap, non-toxic, and recyclable alkaline earth metal that constitutes about 2% weight in the Earth’s crust. The use of magnesium catalysts to forge chiral moieties in molecules is highly attractive. Based on our work in recent years, we describe the current progress in the development of in situ generated magnesium catalysts and their application in asymmetric synthesis. In this perspective, a critically concise classification of in situ generated magnesium catalytic modes, with relevant examples, is presented, and representative mechanisms of each category are discussed. Building on the established diverse strategies, one can foresee that more innovative and structurally creative magnesium catalysts that are generated in situ will be developed to overcome more formidable challenges of catalytic enantioselective reactions.

1 Introduction

2 Magnesium Catalysts Generated in Situ from Chiral Ligands Containing Dual Reactive Hydrogens

3 Magnesium Catalysts Generated in Situ from Monoanionic Chiral Ligands

4 Bimetallic and Polymetallic Magnesium Catalysts Assembled in Situ

5 Summary and Outlook



Publikationsverlauf

Eingereicht: 04. Januar 2021

Angenommen nach Revision: 05. März 2021

Accepted Manuscript online:
05. März 2021

Artikel online veröffentlicht:
07. April 2021

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