Cu-Catalyzed C–H Activation Reaction: One-Pot Direct Synthesis of Xanthine and Uric Acid Derivatives from 5-Bromouracil

Abstract

A one-pot direct synthesis of xanthine and uric acid derivates is reported. This simple yet efficient methodology illustrates concurrent formation of two C–N bonds using CuBr₂ as catalyst and one of those C–N bonds is formed by uracil C6–H bond activation.

Key words

C–H activation - C–N bond formation - xanthine - uric acids - copper - one-pot cyclization

Publication History

Received: 25 May 2021

Accepted after revision: 02 July 2021

Accepted Manuscript online:
02 July 2021

Article published online:
23 July 2021

• References

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