PDF herunterladen
CC BY-NC-ND 4.0 · Endosc Int Open 2021; 09(11): E1740-E1751
DOI: 10.1055/a-1552-3239
Review

Antireflux mucosectomy (ARMS) and antireflux mucosal ablation (ARMA) for gastroesophageal reflux disease: a systematic review and meta-analysis

Enrique Rodríguez de Santiago‡
1   Department of Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), CIBEREHD, Universidad de Alcalá, Madrid, Spain
,
Carlos Teruel Sanchez-Vegazo‡
1   Department of Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), CIBEREHD, Universidad de Alcalá, Madrid, Spain
,
Beatriz Peñas
1   Department of Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), CIBEREHD, Universidad de Alcalá, Madrid, Spain
,
Yuto Shimamura
2   Digestive Disease Center, Showa University Koto Toyosu Hospital, Tokyo, Japan
,
Mayo Tanabe
2   Digestive Disease Center, Showa University Koto Toyosu Hospital, Tokyo, Japan
,
Noelia Álvarez-Díaz
3   Medical library, Hospital Universitario Ramón y Cajal, Madrid, Spain
,
Sofía Parejo
1   Department of Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), CIBEREHD, Universidad de Alcalá, Madrid, Spain
,
Sumi Kazuya
2   Digestive Disease Center, Showa University Koto Toyosu Hospital, Tokyo, Japan
,
Natalia Marcos-Carrasco
1   Department of Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), CIBEREHD, Universidad de Alcalá, Madrid, Spain
,
Enrique Vazquez-Sequeiros
1   Department of Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), CIBEREHD, Universidad de Alcalá, Madrid, Spain
,
Haruhiro Inoue
2   Digestive Disease Center, Showa University Koto Toyosu Hospital, Tokyo, Japan
,
Agustín Albillos
1   Department of Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), CIBEREHD, Universidad de Alcalá, Madrid, Spain
› Institutsangaben
› Weitere Informationen
Auch verfügbar auf
  Lizenzen und Reprints

Abstract

Background and study aims Antireflux mucosectomy (ARMS) and antireflux mucosal ablation (ARMA) are new endoscopic procedures for patients with gastroesophageal reflux disease (GERD). We conducted a meta-analysis to systematically assess the feasibility, clinical success, and safety of these procedures.

Patients and methods We searched Embase, PubMed, and Cochrane Central from inception to October 2020. Overlapping reports, animal studies, and case reports were excluded. Our primary outcomes were clinical success and adverse events (AEs). Secondary outcomes included technical success, endoscopic esophagitis, 24-hour pH monitoring, and proton pump inhibitor (PPI) use. A random effects model was used to pool data.

Results In total, 15 nonrandomized studies (12 ARMS, n = 331; 3 ARMA, n = 130) were included; 10 were conducted in patients with refractory GERD. The technical success rate was 100 %. The pooled short-term (first assessment within the first 6 months), 1-year, and 3-year clinical success rates were 78 % (95 % confidence interval [95 %CI] 70 %–85 %), 72% (95 %CI 47 %–92 %), and 73 % (95 %CI 65 %–81 %), respectively. ARMS and ARMA yielded similar clinical success. The proportion of patients off PPIs at 1 year was 64 % (95 %CI 52 %–75 %). There were significant drops (P < 0.01) in validated clinical questionnaires scores, presence of esophagitis, and acid exposure time. The most common AE (11 %, 95 %CI 8 %–15 %) was dysphagia requiring dilation (7%, 95 %CI 5 %–11 %). Four cases of perforation were recorded, all in patients undergoing ARMS.

Conclusions Our meta-analysis of nonrandomized studies suggests that ARMS and ARMA are safe and effective for patients with GERD.

Supplementary material



Publikationsverlauf

Eingereicht: 17. April 2021

Angenommen: 09. Juli 2021

Artikel online veröffentlicht:
12. November 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Eusebi LH, Ratnakumaran R, Yuan Y. et al. Global prevalence of, and risk factors for, gastro-oesophageal reflux symptoms: a meta-analysis. Gut 2018; 67: 430-440
    CrossrefPubMedSuche in Google Scholar
  • 2 GBD 2017 Gastro-oesophageal Reflux Disease Collaborators. The global, regional, and national burden of gastro-oesophageal reflux disease in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol Hepatol 2020; 5: 561-581
    CrossrefPubMedSuche in Google Scholar
  • 3 Yadlapati R, Vaezi MF, Vela MF. et al. Management options for patients with GERD and persistent symptoms on proton pump inhibitors: recommendations from an expert panel. Am J Gastroenterol 2018; 113: 980-986
    CrossrefPubMedSuche in Google Scholar
  • 4 de la Coba Ortiz C, Argüelles Arias F, Martín de Argila de Prados C. et al. Proton-pump inhibitors adverse effects: a review of the evidence and position statement by the Sociedad Española de Patología Digestiva. Rev Esp Enferm Dig 2016; 108: 207-224
    CrossrefPubMedSuche in Google Scholar
  • 5 Singhal S, Kirkpatrick DR, Masuda T. et al. Primary and redo antireflux surgery: outcomes and lessons learned. J Gastrointest Surg 2018; 22: 177-186
    CrossrefPubMedSuche in Google Scholar
  • 6 Weusten BLAM, Barret M, Bredenoord AJ. et al. Endoscopic management of gastrointestinal motility disorders – part 2: European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy 2020; 52: 600-614
    Thieme ConnectPubMedSuche in Google Scholar
  • 7 Inoue H, Ito H, Ikeda H. et al. Anti-reflux mucosectomy for gastroesophageal reflux disease in the absence of hiatus hernia: A pilot study. Ann Gastroenterol 2014; 27: 346-351
    PubMedSuche in Google Scholar
  • 8 Inoue H, Tanabe M, de Santiago ER. et al. Anti-reflux mucosal ablation (ARMA) as a new treatment for gastroesophageal reflux refractory to proton pump inhibitors: a pilot study. Endosc Int Open 2020; 8: E133-E138
    Thieme ConnectPubMedSuche in Google Scholar
  • 9 Hernández Mondragón OV, Zamarripa Mottú RA, García Contreras LF. et al. Clinical feasibility of a new antireflux ablation therapy on gastroesophageal reflux disease (with video). Gastrointest Endosc 2020; 92: 1190-1201
    CrossrefPubMedSuche in Google Scholar
  • 10 Yoo I, Ko WJ, Kim HS. et al. Anti-reflux mucosectomy using a cap-assisted endoscopic mucosal resection method for refractory gastroesophageal disease: a prospective feasibility study. Surg Endosc 2020; 34: 1124-1131
    CrossrefPubMedSuche in Google Scholar
  • 11 Bapaye A, Mahadik M, Pujari R. et al. Anti-reflux mucosectomy (ARMS) for refractory GERD-Initial clinical experience. J Gastroenterol Hepatol 2017; 32: 255
    PubMedSuche in Google Scholar
  • 12 Monino L, Gonzalez JM, Vitton V. et al. Antireflux mucosectomy band in treatment of refractory gastroesophageal reflux disease: A pilot study for safety, feasibility and symptom control. Endosc Int Open 2020; 8: E147-E154
    Thieme ConnectPubMedSuche in Google Scholar
  • 13 Ma L-L, Wang Y-Y, Yang Z-H. et al. Methodological quality (risk of bias) assessment tools for primary and secondary medical studies: what are they and which is better?. Mil Med Res 2020; 7: 7
    CrossrefPubMedSuche in Google Scholar
  • 14 Higgins JP, Thomas J, Chandler J. et al. Cochrane handbook for systematic reviews of interventions. John Wiley & Sons; 2019
    PubMedSuche in Google Scholar
  • 15 Barendregt JJ, Doi SA, Lee YY. et al. Meta-analysis of prevalence. J Epidemiol Community Health 2013; 67: 974-978
    CrossrefPubMedSuche in Google Scholar
  • 16 Wan X, Wang W, Liu J. et al. Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. BMC Med Res Methodol 2014; 14: 135
    CrossrefPubMedSuche in Google Scholar
  • 17 Spechler SJ, Hunter JG, Jones KM. et al. Randomized Trial of Medical versus Surgical Treatment for Refractory Heartburn. N Engl J Med 2019; 381: 1513-1523
    CrossrefPubMedSuche in Google Scholar
  • 18 Sumi K, Inoue H, Kobayashi Y. et al. Endoscopic treatment of proton pump inhibitor-refractory gastroesophageal reflux disease with anti-reflux mucosectomy: Experience of 109 cases. Dig Endosc 2020;
    CrossrefPubMedSuche in Google Scholar
  • 19 Patil G, Dalal A, Maydeo A. Feasibility and outcomes of anti-reflux mucosectomy for proton pump inhibitor dependent gastroesophageal reflux disease: First Indian study (with video). Dig Endosc 2020; 32: 745-752
    CrossrefPubMedSuche in Google Scholar
  • 20 Debourdeau A, Vitton V, Monino L. et al. Antireflux Mucosectomy Band (ARM-b) in treatment of refractory gastroesophageal reflux disease after bariatric surgery. Obes Surg 2020; 30: 4654-4658
    CrossrefPubMedSuche in Google Scholar
  • 21 Ota K, Takeuchi T, Harada S. et al. A novel endoscopic submucosal dissection technique for proton pump inhibitor-refractory gastroesophageal reflux disease. Scand J Gastroenterol 2014; 49: 1409-1413
    CrossrefPubMedSuche in Google Scholar
  • 22 Wong HJ, Su B, Attaar M. et al. Anti-reflux mucosectomy (ARMS) results in improved recovery and similar reflux quality of life outcomes compared to laparoscopic Nissen fundoplication. Surg Endosc 2020;
    CrossrefPubMedSuche in Google Scholar
  • 23 Vasilevskiy DI, Bagnenko SF, Smirnov A. et al. Antireflux mucosectomy (Arms) in the treatment of patients with gerd and columnar-cell lined (barrett’s) esophagus. First experiences. Surg Endosc 2017; 31: S405
    PubMedSuche in Google Scholar
  • 24 Shah R, Maydeo AP, Dhir V. Anti reflux mucosectomy (ARMS) for refractory gastro esophageal reflux disease (GERD)-are we there yet?. United European Gastroenterol J 2017; 5: A354-A355
    PubMedSuche in Google Scholar
  • 25 Ortega A, Rosón P, Fern F. et al. Antireflux mucosectomy. preliminary results of a prospective study. Endoscopy 2019; 51: S240-S241
    PubMedSuche in Google Scholar
  • 26 Mohan PrasadVG, Appadurai S, Suman MP. Anti-reflux mucosectomy (ARMS) for refractory GERD-Our 3yrs experience. J Gastroenterol Hepatol 2019; 34: 232
    PubMedSuche in Google Scholar
  • 27 Hernández Mondragón OV, Pintor JC, Gutierrez Aguilar RA. et al. Antireflux ablation therapy (ARAT), for reflux disease after poem procedure. Early clinical experience. Gastrointest Endosc 2020; 91: AB130
    CrossrefPubMedSuche in Google Scholar
  • 28 Fass R, Cahn F, Scotti DJ. et al. Systematic review and meta-analysis of controlled and prospective cohort efficacy studies of endoscopic radiofrequency for treatment of gastroesophageal reflux disease. Surg Endosc 2017; 31: 4865-4882
    CrossrefPubMedSuche in Google Scholar
  • 29 Garg SK, Gurusamy KS. Laparoscopic fundoplication surgery versus medical management for gastro-oesophageal reflux disease (GORD) in adults. Cochrane Database Syst Rev; 2015: CD003243
    PubMedSuche in Google Scholar
  • 30 Li X, Zhang W, Chen M. et al. A Prospective randomized trial to assess the antireflux effect of antireflux mucosectomy in the porcine model. Gastroenterol Res Pract 2019;
    CrossrefPubMedSuche in Google Scholar
  • 31 McCarty TR, Itidiare M, Njei B. et al. Efficacy of transoral incisionless fundoplication for refractory gastroesophageal reflux disease: a systematic review and meta-analysis. Endoscopy 2018; 50: 708-725
    Thieme ConnectPubMedSuche in Google Scholar
  • 32 Schuitenmaker JM, van Hoeij FB, Schijven MP. et al. Pneumatic dilation for persistent dysphagia after antireflux surgery, a multicentre single-blind randomised sham-controlled clinical trial. Gut 2021;
    CrossrefPubMedSuche in Google Scholar
  • 33 Cremonini F, Ziogas DC, Chang HY. et al. Meta-analysis: the effects of placebo treatment on gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2010; 32: 29-42
    CrossrefPubMedSuche in Google Scholar