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Synthesis 2022; 54(21): 4764-4772
DOI: 10.1055/a-1683-9455
DOI: 10.1055/a-1683-9455
special topic
Asymmetric C–H Functionalization
Cationic Iridium/Chiral Bidentate Phosphoramidite Catalyzed Asymmetric Hydroarylation


Abstract
In this personal account, we summarize our investigations on the asymmetric direct addition of C(sp2)–H bonds to unsaturated bonds, such as C=O and C=C, using cationic iridium/chiral O-linked bidentate phosphoramidite (Me-BIPAM) and S-linked bidentate phosphoramidite (S-Me-BIPAM) catalyst systems.
1 Introduction
2 Highly Enantioselective Intramolecular Hydroarylation of α-Keto Amides
3 Highly Enantioselective Intermolecular Hydroarylation of Bicycloalkenes
4 Conclusion
Key words
asymmetric synthesis - C–H functionalization - hydroarylation - iridium catalysts - chiral bidentate phosphoramiditesPublikationsverlauf
Eingereicht: 05. Oktober 2021
Angenommen nach Revision: 01. November 2021
Accepted Manuscript online:
01. November 2021
Artikel online veröffentlicht:
14. Dezember 2021
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