Progress in the Synthesis of N-Acyl-N,O-acetals

Xiao-Yan Ma; Fu-Qiang Shao; Xinjun Hu; Xingyong Liu

doi:10.1055/a-1684-0772

Synthesis, Table of Contents

Synthesis 2022; 54(05): 1203-1216
DOI: 10.1055/a-1684-0772

short review

Progress in the Synthesis of N-Acyl-N,O-acetals

Xiao-Yan Ma∗

^aSchool of Chemical Engineering, Sichuan University of Science & Engineering, Zigong, 643000, P. R. China

,

Fu-Qiang Shao‡

^bDepartment of Nuclear Medicine, Zigong First People's Hospital & Zigong Academy of Medical Sciences, Zigong, Sichuan 643000, P. R. China

,

Xinjun Hu

^aSchool of Chemical Engineering, Sichuan University of Science & Engineering, Zigong, 643000, P. R. China

^cGraphene Institute of Lanzhou University Fangda Carbon, Key Laboratory of Special Function Materials and Structure Design of Ministry of Education, Lanzhou University, Lanzhou 730000, P. R. China

,

Xingyong Liu

^aSchool of Chemical Engineering, Sichuan University of Science & Engineering, Zigong, 643000, P. R. China

› Author Affiliations

Abstract

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Abstract

N-Acyl-N,O-acetals are key components in a variety of bioactive natural products. Furthermore, they are synthetic equivalents of unstable N-acylimines and building blocks in organic synthesis. Tremendous efforts have been made in the synthesis of such acetals, these methods can be broadly classified into two categories: electrochemical oxidation and chemical methods. Herein, we will summarize progress in the preparation of these subunits, which may aid the development of new synthetic methods for N-acyl-N,O-acetals.

1 Introduction

2 Synthetic Methods for Preparing N-Acyl-N,O-acetals

2.1 Electrochemical Oxidation

2.2 Chemical Methods

2.3 Other Methods

3 Summary and Outlook

Key words

N-acyl-N,O-acetal - natural products - synthetic equivalent - electrochemical oxidation - chemical method

Full Text

References

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