Cystatin C Concentration During the First Three Postnatal Days in
                    Healthy Term Newborns

Vinka Mikulic; Dunja Rogic; Ivanka Mikulic; Marjana Jerkovic Raguz; Jerko Brzica; Maja Pandza Topic; Kristina Ljubić; Vajdana Tomic

doi:10.1055/a-1727-6309

Zeitschrift für Geburtshilfe und Neonatologie, Table of Contents

Z Geburtshilfe Neonatol 2022; 226(03): 193-196
DOI: 10.1055/a-1727-6309

Original Article

Cystatin C Concentration During the First Three Postnatal Days in Healthy Term Newborns

Vinka Mikulic

¹Department of Laboratory Diagnostics, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina

²Clinical Biochemistry, University of Mostar, School of Medicine, Mostar, Bosnia and Herzegovina

,

Dunja Rogic

³Department of Laboratory Diagnostics, University Hospital Center Zagreb, Zagreb, Croatia

⁴Department of Medical Biochemistry and Hematology, University of Zagreb Faculty of Pharmacy and Biochemistry, Zagreb, Croatia

,

Ivanka Mikulic

¹Department of Laboratory Diagnostics, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina

²Clinical Biochemistry, University of Mostar, School of Medicine, Mostar, Bosnia and Herzegovina

,

Marjana Jerkovic Raguz

⁵Department of Pediatrics, University of Mostar, School of Medicine, Mostra, Bosnia and Herzegovina

⁶Department of Neonatology and Intensive Care Unit, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina

,

Jerko Brzica

⁵Department of Pediatrics, University of Mostar, School of Medicine, Mostra, Bosnia and Herzegovina

⁶Department of Neonatology and Intensive Care Unit, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina

,

Maja Pandza Topic

⁷Department of Psychology, University of Mostar Faculty of Philosophy, Mostar, Bosnia and Herzegovina

,

Kristina Ljubić

¹Department of Laboratory Diagnostics, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina

²Clinical Biochemistry, University of Mostar, School of Medicine, Mostar, Bosnia and Herzegovina

,

Vajdana Tomic

⁸Department of Obstetrics and Gynaecology, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina

⁹Department of Gynaecology, University of Mostar School of Medicine, Mostar, Bosnia and Herzegovina

› Author Affiliations

Abstract

Objective Cystatin C (Cys-C) concentration has not been examined sufficiently among healthy newborn population, particularly in terms of reference values. This study aimed to establish gender-, postnatal age- and birth weight-specific Cys-C concentration for healthy term newborns. Its objective was also to examine if there were any differences between our measured concentration and the reference interval established by the CALIPER study.

Methods Serum samples from a total of 90 healthy term newborns were used to determine Cys-C concentration. Cys-C was measured within first three days of birth using particle-enhanced turbidimetric immunoassay (PETIA) on the Architect plus ci8200 analyzer.

Results Median concentration of the Cys-C was 2.05 mg/L. There were no statistically significant differences in Cys-C concentration regarding gender (p=0.779), birth weight (p=0.505), postnatal age (p=0.512) or Apgar score (p=0.799). The value of the 2.5th and 97.5th percentile for Cys-C concentrations for girls was 0.93–3.15 mg/L and for boys it was 1.5–3.36 mg/L.

Conclusion Cys-C concentration in healthy term newborns does not depend on gender, birth weight, postnatal age, or Apgar score. Our measured concentration range of CyS-C in healthy newborns turned out to be slightly wider than the interval determined in the CALIPER study.

Key words

Cystatin C - Newborn - Kidney - Reference values

Full Text

References

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