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Z Geburtshilfe Neonatol 2022; 226(03): 193-196
DOI: 10.1055/a-1727-6309
Original Article

Cystatin C Concentration During the First Three Postnatal Days in Healthy Term Newborns

Vinka Mikulic 
1   Department of Laboratory Diagnostics, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
2   Clinical Biochemistry, University of Mostar, School of Medicine, Mostar, Bosnia and Herzegovina
,
Dunja Rogic
3   Department of Laboratory Diagnostics, University Hospital Center Zagreb, Zagreb, Croatia
4   Department of Medical Biochemistry and Hematology, University of Zagreb Faculty of Pharmacy and Biochemistry, Zagreb, Croatia
,
Ivanka Mikulic
1   Department of Laboratory Diagnostics, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
2   Clinical Biochemistry, University of Mostar, School of Medicine, Mostar, Bosnia and Herzegovina
,
Marjana Jerkovic Raguz 
5   Department of Pediatrics, University of Mostar, School of Medicine, Mostra, Bosnia and Herzegovina
6   Department of Neonatology and Intensive Care Unit, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
,
Jerko Brzica
5   Department of Pediatrics, University of Mostar, School of Medicine, Mostra, Bosnia and Herzegovina
6   Department of Neonatology and Intensive Care Unit, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
,
Maja Pandza Topic
7   Department of Psychology, University of Mostar Faculty of Philosophy, Mostar, Bosnia and Herzegovina
,
Kristina Ljubić
1   Department of Laboratory Diagnostics, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
2   Clinical Biochemistry, University of Mostar, School of Medicine, Mostar, Bosnia and Herzegovina
,
Vajdana Tomic
8   Department of Obstetrics and Gynaecology, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
9   Department of Gynaecology, University of Mostar School of Medicine, Mostar, Bosnia and Herzegovina
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Abstract

Objective Cystatin C (Cys-C) concentration has not been examined sufficiently among healthy newborn population, particularly in terms of reference values. This study aimed to establish gender-, postnatal age- and birth weight-specific Cys-C concentration for healthy term newborns. Its objective was also to examine if there were any differences between our measured concentration and the reference interval established by the CALIPER study.

Methods Serum samples from a total of 90 healthy term newborns were used to determine Cys-C concentration. Cys-C was measured within first three days of birth using particle-enhanced turbidimetric immunoassay (PETIA) on the Architect plus ci8200 analyzer.

Results Median concentration of the Cys-C was 2.05 mg/L. There were no statistically significant differences in Cys-C concentration regarding gender (p=0.779), birth weight (p=0.505), postnatal age (p=0.512) or Apgar score (p=0.799). The value of the 2.5th and 97.5th percentile for Cys-C concentrations for girls was 0.93–3.15 mg/L and for boys it was 1.5–3.36 mg/L.

Conclusion Cys-C concentration in healthy term newborns does not depend on gender, birth weight, postnatal age, or Apgar score. Our measured concentration range of CyS-C in healthy newborns turned out to be slightly wider than the interval determined in the CALIPER study.

Key words

Cystatin C - Newborn - Kidney - Reference values


Publication History

Received: 21 September 2021

Accepted: 10 December 2021

Article published online:
26 January 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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