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CC BY-NC-ND 4.0 · Endosc Int Open 2022; 10(05): E572-E579
DOI: 10.1055/a-1784-6723
Original article

Efficacy of specimen pasting after cold snare polypectomy for pathological evaluation of horizontal margins

Takuya Ikeda
1   Department of Clinical laboratory Osaka Saiseikai Nakatsu Hospital, Osaka, Japan
,
Tetsuya Yoshizaki
2   Department of Gastroenterology Osaka Saiseikai Nakatsu Hospital, Osaka, Japan
3   Department of Gastroenterology Kobe University Graduate School of Medicine, Kobe, Japan
,
Takaaki Eguchi
2   Department of Gastroenterology Osaka Saiseikai Nakatsu Hospital, Osaka, Japan
,
Hiroshi Kinugasa
1   Department of Clinical laboratory Osaka Saiseikai Nakatsu Hospital, Osaka, Japan
,
Akihiko Okada
2   Department of Gastroenterology Osaka Saiseikai Nakatsu Hospital, Osaka, Japan
› Author AffiliationsTRIAL REGISTRATION: Single-Center, Randomized, prospective trial at www.umin.ac.jp
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Cold or hot snare in endoscopy – that is the questionEndosc Int Open 2022; 10(05): E580-E581
DOI: 10.1055/a-1776-7685

Abstract

Background and study aims Several studies have reported that pathological horizontal margin evaluation cannot be diagnosed in cold snare polypectomy (CSP) specimens. We conducted a prospective randomized controlled trial to determine the efficacy of pasting CSP specimens on paper for pathological horizontal margins.

Patients and methods This was a single-center, prospective study conducted at Osaka Saiseikai Nakatsu Hospital. In this study, the indications for CSP were adenomas ≤ 10 mm. Colorectal polyps resected by CSP were randomized to the pasting and non-pasting groups after exclusion of fragmented specimens, and the extended CSP specimens pasted on paper were formalin-fixed in the pasting group. The primary endpoint was rate of unclear horizontal margins after CSP.

Results A total of 216 CSP specimens were analyzed. The rate of unclear horizontal margins was significantly lower in the pasting group than in the non-pasting group (15.1 % vs 33.6 %, P = 0.002). CSP specimen pasting significantly reduced the rate of unclear horizontal margins. On multivariate analysis, non-pasting group (odds ratio [OR], 2.69; 95 % confidence interval [CI], 1.38–5.41; P = 0.003) and right colon (OR, 1.98; 95 %CI, 1.01–4.01; P = 0.047) were independent risk factors for unclear horizontal margins in CSP specimens.

Conclusions Pasting the extended specimen is important for accurate pathological examination after CSP.

Supplementary material



Publication History

Received: 07 December 2021

Accepted: 03 January 2022

Article published online:
13 May 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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Comment to this article:

Endoscopy International Open – recently publishedEndoscopy 2022; 54(06): 631-631
DOI: 10.1055/a-1748-1088

 

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