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CC BY-NC-ND 4.0 · Endosc Int Open 2022; 10(05): E593-E601
DOI: 10.1055/a-1784-7063
Original article

Advanced endoscopic resection for colorectal dysplasia in inflammatory bowel disease: a meta-analysis

Sonmoon Mohapatra
1   Division of Gastroenterology and Hepatology, Saint Peter’s University Hospital – Rutgers Robert Wood Johnson School of Medicine, New Brunswick, New Jersey, United States
2   Department of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, Maryland, United States
,
Kesavan Sankaramangalam
1   Division of Gastroenterology and Hepatology, Saint Peter’s University Hospital – Rutgers Robert Wood Johnson School of Medicine, New Brunswick, New Jersey, United States
,
Chawin Lopimpisuth
2   Department of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, Maryland, United States
,
Oluwatoba Moninuola
1   Division of Gastroenterology and Hepatology, Saint Peter’s University Hospital – Rutgers Robert Wood Johnson School of Medicine, New Brunswick, New Jersey, United States
,
Malorie Simons
2   Department of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, Maryland, United States
,
Julie Nanavati
3   Welch Medical Library, Johns Hopkins University, Baltimore, Maryland, United States
,
Leah Jager
4   Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland, United States
,
Debra Goldstein
1   Division of Gastroenterology and Hepatology, Saint Peter’s University Hospital – Rutgers Robert Wood Johnson School of Medicine, New Brunswick, New Jersey, United States
,
Arkady Broder
1   Division of Gastroenterology and Hepatology, Saint Peter’s University Hospital – Rutgers Robert Wood Johnson School of Medicine, New Brunswick, New Jersey, United States
,
Venkata Akshintala
2   Department of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, Maryland, United States
,
Reezwana Chowdhury
2   Department of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, Maryland, United States
,
Alyssa Parian
2   Department of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, Maryland, United States
,
Mark G. Lazarev
2   Department of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, Maryland, United States
,
Saowanee Ngamruengphong
2   Department of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, Maryland, United States
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Abstract

Background and study aims Little is known about outcomes of advanced endoscopic resection (ER) for patients with inflammatory bowel disease (IBD) with dysplasia. The aim of our meta-analysis was to estimate the safety and efficacy of endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) for dysplastic lesions in patients with IBD.

Methods We performed a systematic review through Jan 2021 to identify studies of IBD with dysplasia that was treated by EMR or ESD. We estimated the pooled rates of complete ER, adverse events, post-ER surgery, and recurrence. Proportions were pooled by random effect models.

Results Eleven studies including 506 patients and 610 lesions were included. Mean lesion size was 23 mm. The pooled rate of complete ER was 97.9 % (95 % confidence interval [CI]: 95.3 % to 99.7 %). The pooled rate of endoscopic perforation was 0.8 % (95 % CI:0.1 % to 2.2 %) while bleeding occurred in 1.6 % of patients (95 %CI:0.4 % to 3.3 %). Overall, 6.6 % of patients (95 %CI:3.6 % to 10.2 %) underwent surgery after an ER. Among 471 patients who underwent surveillance, local recurrence occurred in 4.9 % patients (95 % CI:1.0 % to 10.7 %) and metachronous lesions occurred in 7.4 % patients (95 %CI:1.5 % to 16 %) over a median follow-up of 33 months. Metachronous colorectal cancer (CRC) was detected in 0.2 % of patients (95 %CI:0 % to 2.2 %) during the surveillance period.

Conclusions Advanced ER is safe and effective in the management of large dysplastic lesions in IBD and warrants consideration as first-line therapy. Although the risk of developing CRC after ER is low, meticulous endoscopic surveillance is crucial to monitor for local or metachronous recurrence of dysplasia.

Supplementary material



Publication History

Received: 10 October 2021

Accepted after revision: 26 November 2021

Article published online:
13 May 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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