Stress and Its Consequences—Biological Strain

David K. Stevenson; Ian H. Gotlib; Jessica L. Buthmann; Ivana Marié; Nima Aghaeepour; Brice Gaudilliere; Martin S. Angst; Gary L. Darmstadt; Maurice L. Druzin; Ronald J. Wong; Gary M. Shaw; Michael Katz

doi:10.1055/a-1798-1602

American Journal of Perinatology, Inhaltsverzeichnis

Am J Perinatol 2024; 41(09): 1282-1284
DOI: 10.1055/a-1798-1602

Commentary

Stress and Its Consequences—Biological Strain

David K. Stevenson

¹Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California

,

Ian H. Gotlib

²Department of Psychology, Stanford University School of Humanities and Science, Stanford, California

,

Jessica L. Buthmann

²Department of Psychology, Stanford University School of Humanities and Science, Stanford, California

,

Ivana Marié

¹Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California

,

Nima Aghaeepour

³Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California

,

Brice Gaudilliere

³Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California

,

Martin S. Angst

³Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California

,

Gary L. Darmstadt

¹Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California

,

Maurice L. Druzin

⁴Department of Obstetrics and Gynecology—Maternal-Fetal Medicine, Stanford University School of Medicine, Stanford, California

,

Ronald J. Wong

¹Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California

,

Gary M. Shaw

¹Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California

,

Michael Katz

¹Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California

› Institutsangaben

Abstract

Understanding the role of stress in pregnancy and its consequences is important, particularly given documented associations between maternal stress and preterm birth and other pathological outcomes. Physical and psychological stressors can elicit the same biological responses, known as biological strain. Chronic stressors, like poverty and racism (race-based discriminatory treatment), may create a legacy or trajectory of biological strain that no amount of coping can relieve in the absence of larger-scale socio-behavioral or societal changes. An integrative approach that takes into consideration simultaneously social and biological determinants of stress may provide the best insights into the risk of preterm birth. The most successful computational approaches and the most predictive machine-learning models are likely to be those that combine information about the stressors and the biological strain (for example, as measured by different omics) experienced during pregnancy.

Keywords

pregnancy - preterm birth - omics - machine learning

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Referenzen

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