Enantioselective Synthesis of Axially Chiral Benzimidazoles ­Bearing a C–N axis via Pd-Catalyzed Buchwald–Hartwig ­Amination

Abstract

Benzimidazole atropisomers bearing a C–N axis are privileged structural frameworks in pharmaceutical and natural products, thus appealing an increasing interest for its asymmetric synthesis. Here, we briefly discuss recent advances in the asymmetric synthesis of benzimidazole atropisomers with a C–N axis, with particular attention to our recently developed palladium-catalyzed intramolecular Buchwald–Hartwig amination strategy.

Key words

atropisomerism - palladium - amination - benzimidazole atropisomers - asymmetric catalysis

Publication History

Received: 12 April 2022

Accepted after revision: 23 April 2022

Accepted Manuscript online:
25 April 2022

Article published online:
19 May 2022

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