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CC BY-NC-ND 4.0 · Endosc Int Open 2022; 10(08): E1029-E1036
DOI: 10.1055/a-1854-4587
Original article

Non-cardia early gastric cancer in Central Vietnam: noticeable uncommon background mucosa and results of endoscopic submucosal dissection

Van Huy Tran
1   Gastrointestinal Endoscopy Center, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam
,
Quang Trung Tran
1   Gastrointestinal Endoscopy Center, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam
2   Department of Internal Medicine A, University Medicine Greifswald, Germany
,
Thi Huyen Thuong Nguyen
1   Gastrointestinal Endoscopy Center, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam
,
Cong Thuan Dang
3   Pathology Department, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam
,
Markus M. Lerch
2   Department of Internal Medicine A, University Medicine Greifswald, Germany
,
Ali A. Aghdassi
2   Department of Internal Medicine A, University Medicine Greifswald, Germany
,
Ryoji Miayahara
4   Gastroenterology & Hepatology Department, Fujita Health University, Toyoake, Japan
› Author Affiliationshttp://dx.doi.org/10.13039/501100001659
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Non-cardia early gastric cancer in Central Vietnam: noticeable uncommon background mucosa and results of endoscopic submucosal dissectionEndosc Int Open 2022; 10(08): C7-C7
DOI: 10.1055/a-1925-4922

Abstract

Background and study aims Gastric cancer (GC) is one of the leading causes of malignancy-related death in Vietnam, with increasing incidence of non-cardia early gastric cancer (N-EGC). Data on accurate diagnosis of EGC and treatment by endoscopic submucosal dissection (ESD) in Vietnam are very sparse. The aim of this study was to describe the characteristics of N-EGC and evaluate the effectiveness and the safety of ESD in Central Vietnam.

Patients and methods We prospectively enrolled patients with N-EGC detected by magnified chromoendoscopy from December 2013 to August, 2018 in Central Vietnam. Selected cases of N-EGC received standardized ESD technique and have been following up carefully as in protocol.

Results Among 606 GC patients, 46 had N-GEC and underwent ESD. The depth of invasion was pT1a in 33 (71.7 %), pT1b1 in 10 (21.7 %), and pT1b2 in three cases (6.6 %). Mild chronic atrophic gastritis, most being C2 (63 %), and gastritis-like EGC that did not appear malignant was the predominant type. ESD achieved a 97.8 % en bloc resection rate; the mean procedure time was 76 ± 22 minutes (range 24–155), and mean endoscopic tumor size was 23 ± 5 mm (range 13–52) and ESD sample size was 28 ± 7 mm (range 16.5–60). Complications consisted of two patients with bleeding and one with a minor perforation, all of which were successfully managed by endoscopy. The longest and the mean follow-up times were 84 and 64 months, respectively, with no recurrence.

Conclusions A significant proportion patients with N-EGC have a background mucosa of mild chronic atrophic gastritis. Our results 7 years after starting ESD demonstrate early promising outcomes with the procedure.



Publication History

Received: 04 June 2021

Accepted after revision: 31 December 2021

Article published online:
15 August 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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