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DOI: 10.1055/a-1872-0179
Versatile OPiv-Supported Organozinc Reagents for Transition-Metal-Catalyzed Cross-Couplings
Support by the start-up grant (No. GJ10900220) of Soochow University is gratefully acknowledged.
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Dedicated to Prof. Ei-ichi Negishi and Paul Knochel for their brilliant contributions in organic chemistry
Abstract
As one of the most important indispensable tools, organozinc-reagents-based Negishi cross-couplings have been extensively utilized for the synthesis of biologically active molecules and feedstock commodity chemicals. However, the use of air- and moisture-sensitive organozinc halides and expensive palladium catalysis still remain drawbacks. Recently, user-friendly solid OPiv-supported C–Zn, Si–Zn reagents with enhanced air and moisture stability have been prepared, which displayed superior reactivity in various transition-metal-catalyzed cross-couplings, especially in the earth-abundance cobalt and nickel catalysis. Herein, we summarized the recent advances and our research work in the field of the preparation and application of solid organozinc pivalates in the present short review.
1 Introduction
2 Development of Organozinc Pivalates in Two-Component Cross-Couplings
3 Development of Organozinc Pivalates in Three-Component Cross-Couplings
4 Conclusion and Outlook
Key words
organozinc pivalates - silylzinc pivalates - Negishi coupling - alkene difunctionalization - homogeneous catalysisPublikationsverlauf
Eingereicht: 23. Mai 2022
Angenommen nach Revision: 09. Juni 2022
Accepted Manuscript online:
09. Juni 2022
Artikel online veröffentlicht:
20. Juli 2022
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Also see the applications of alkynylzinc pivalates in cobalt catalysis: