Oral Cimetidine as an Adjuvant Therapy for Condyloma Acuminata

Abstract

Introduction Condyloma acuminata (CA) is a sexually transmitted infection caused by the human papillomavirus (HPV), and the recurrence rate is relatively high. A compromised immune system causes CA recurrence. The primary treatment goal is to eradicate the warts; however, the immunomodulatory combination therapy might reduce the recurrence rate, so it might enhance the healing process. Cimetidine is a histamine H2-receptor antagonist which might indicate immunomodulator activity.

Aim This case report aimed to investigate the effectiveness of cimetidine as an immunomodulator agent against CA.

Clinical cases Three patients visited dermatology and venerology outpatient clinic with multiple warts located on the external genital and perianal area. The examination described there were confluent cauliflower-like nodules. Besides, acetowhite examination showed positive reactions. Two patients were HIV-positve and one was negative. The lesions showed clinical improvement in all three patients.

Conclusion Briefly, the cimetidine is effective as an immunomodulator therapy to enhance the healing process and decrease the risk of CA recurrences.

Keywords

cimetidine - condyloma acuminata - H2-receptor antagonist - warts

Publication History

Article published online:
20 October 2022

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