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DOI: 10.1055/a-1876-2616
Differentialdiagnose Vaskulitis und Vaskulopathie aus dermatologischer Sicht
Differential Diagnosis of Vasculitis and Vasculopathy from a Dermatological Point of ViewZusammenfassung
Vaskulopathien und Vaskulitiden stellen diagnostisch und therapeutisch eine interdisziplinäre Herausforderung dar. Zugrunde liegen unterschiedliche pathophysiologische Mechanismen, die zu vielfältigen klinischen Krankheitsbildern führen können und therapeutisch unterschiedliche Ansätze erlauben. Sowohl Vaskulitiden als auch Vaskulopathien müssen nicht zwangsläufig mit einer Systembeteiligung einhergehen, sondern können auch als rein kutane Varianten auftreten. Aufgrund mangelnder pathognomonischer Laborparameter ist die Diagnose häufig klinisch zu stellen. Dieser Artikel soll den differentialdiagnostischen Blick, insbesondere auf die kutanen Manifestationsformen bei Vaskulopathien und Vaskulitiden, schärfen.
Abstract
Vasculopathies and vasculitides pose an interdisciplinary challenge in terms of diagnosis and therapy. They are based on different pathophysiological mechanisms that can lead to clinical symptoms and allow different therapeutic approaches. Neither vasculitides nor vasculopathies have necessarily to be associated with systemic involvement, but can also occur as purely cutaneous variants. Due to the lack of pathognomonic laboratory parameters, the diagnosis is often clinical. This article is intended to focus on the differential diagnostic view, particularly in the case of cutaneous manifestations of vasculitis and vasculopathies.
Publikationsverlauf
Artikel online veröffentlicht:
11. August 2022
© 2022. Thieme. All rights reserved.
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Germany
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Literatur
- 1 Jennette JC, Falk RJ, Bacon PA. et al. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum 2013; 65: 1-11
- 2 Mitschang C, Görge T. Diagnosis and treatment of vasculitic ulcerations. Hautarzt 2020; 71: 870-879
- 3 Sunderkötter CH, Zelger B, Chen K-R. et al. Nomenclature of Cutaneous Vasculitis: Dermatologic Addendum to the 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheumatol 2018; 70: 171-184
- 4 Sunderkötter C, Roth J, Bonsmann G. Leukocytoclastic vasculitis. Hautarzt 2004; 55: 759-783 quiz 784-5
- 5 Díaz-Pérez JL, De Lagrán ZM, Díaz-Ramón JL. et al. Cutaneous polyarteritis nodosa. Semin Cutan Med Surg 2007; 26: 77-86
- 6 Tsianakas A, Ehrchen JM, Presser D. et al. Scalp necrosis in giant cell arteritis: case report and review of the relevance of this cutaneous sign of large-vessel vasculitis. J Am Acad Dermatol 2009; 61: 701-706
- 7 Gonzalez CD, Florell SR, Bowen AR. et al. Histopathologic vasculitis from the periulcer edge: A retrospective cohort study. J Am Acad Dermatol 2019; 81: 1353-1357
- 8 Pillebout E, Sunderkötter C. IgA vasculitis. Semin Immunopathol 2021; 43: 729-738
- 9 Schirmer JH, Aries PM, de Groot K. et al. S1 guidelines Diagnostics and treatment of ANCA-associated vasculitis. Z Rheumatol 2017; 76: 77-104
- 10 Aries PM, Hellmich B, Gross WL. Diagnosis und therapy of ANCA-associated vasculitis. Dtsch Med Wochenschr 2006; 131: 443-446
- 11 Sunderkötter C. Vaskulitis und Vaskulopathien. In: Plewig G, Ruzicka T, Kaufmann R, Hertl M, Hrsg. Braun-Falco’s Dermatologie, Venerologie und Allergologie. Berlin, Heidelberg: Springer Berlin Heidelberg; 2018: 1139-1182
- 12 Marzano AV, Raimondo MG, Berti E. et al. Cutaneous Manifestations of ANCA-Associated Small Vessels Vasculitis. Clin Rev Allergy Immunol 2017; 53: 428-438
- 13 Berden AE, Ferrario F, Hagen EC. et al. Histopathologic classification of ANCA-associated glomerulonephritis. J Am Soc Nephrol 2010; 21: 1628-1636
- 14 Aasarød K, Bostad L, Hammerstrøm J. et al. Renal histopathology and clinical course in 94 patients with Wegener’s granulomatosis. Nephrol Dial Transplant 2001; 16: 953-960
- 15 Hauer HA, Bajema IM, van Houwelingen HC. et al. Determinants of outcome in ANCA-associated glomerulonephritis: a prospective clinico-histopathological analysis of 96 patients. Kidney Int 2002; 62: 1732-1742
- 16 Kluger N, Pagnoux C, Guillevin L. et al. Comparison of cutaneous manifestations in systemic polyarteritis nodosa and microscopic polyangiitis. Br J Dermatol 2008; 159: 615-620
- 17 Ratzinger G, Zelger BG, Carlson JA. et al. Vasculitic wheel – an algorithmic approach to cutaneous vasculitides. J Dtsch Dermatol Ges 2015; 13: 1092-1117
- 18 Munera-Campos M, Bielsa I, Martínez-Morillo M. et al. Manifestations, clinical course and prognostic markers in cutaneous polyarteritis nodosa. J Dtsch Dermatol Ges 2020; 18: 1250-1259
- 19 de Boysson H, Guillevin L. Polyarteritis Nodosa Neurologic Manifestations. Neurol Clin 2019; 37: 345-357
- 20 Morgan AJ, Schwartz RA. Cutaneous polyarteritis nodosa: a comprehensive review. Int J Dermatol 2010; 49: 750-756
- 21 Ricotti C, Kowalczyk JP, Ghersi M. et al. The diagnostic yield of histopathologic sampling techniques in PAN-associated cutaneous ulcers. Arch Dermatol 2007; 143: 1334-1336
- 22 Bauzá A, España A, Idoate M. Cutaneous polyarteritis nodosa. Br J Dermatol 2002; 146: 694-699
- 23 Diaz-Perez JL, Schroeter AL, Winkelmann RK. Cutaneous periarteritis nodosa: immunofluorescence studies. Arch Dermatol 1980; 116: 56-58
- 24 Rogalski C, Sticherling M. Panarteritis cutanea benigna--an entity limited to the skin or cutaneous presentation of a systemic necrotizing vasculitis? Report of seven cases and review of the literature. Int J Dermatol 2007; 46: 817-821
- 25 Daoud MS, Hutton KP, Gibson LE. Cutaneous periarteritis nodosa: a clinicopathological study of 79 cases. Br J Dermatol 1997; 136: 706-713
- 26 Boehm I, Bauer R. Low-dose methotrexate controls a severe form of polyarteritis nodosa. Arch Dermatol 2000; 136: 167-169
- 27 Lobo I, Ferreira M, Silva E. et al. Cutaneous polyarteritis nodosa treated with intravenous immunoglobulins. J Eur Acad Dermatol Venereol 2008; 22: 880-882
- 28 Buttgereit F, Dejaco C, Matteson EL. et al. Polymyalgia Rheumatica and Giant Cell Arteritis: A Systematic Review. JAMA 2016; 315: 2442-2458
- 29 Wang X, Hu ZP, Lu W. et al. Giant cell arteritis. Rheumatol Int 2008; 29: 1-7
- 30 Tago M, Oishi T, Makio S. et al. Tongue Necrosis: An Atypical Sign of Giant-cell Arteritis. Intern Med 2021; 60: 3347-3348
- 31 Chua-Aguilera CJ, Möller B, Yawalkar N. Skin Manifestations of Rheumatoid Arthritis, Juvenile Idiopathic Arthritis, and Spondyloarthritides. Clin Rev Allergy Immunol 2017; 53: 371-393
- 32 Cojocaru M, Cohocaru IM, Chico B. New insight into the rheumatoid vasculitis. Rom J Intern Med 2015; 53: 128-132
- 33 McRorie ER, Ruckley CV, Nuki G. The relevance of large-vessel vascular disease and restricted ankle movement to the aetiology of leg ulceration in rheumatoid arthritis. Br J Rheumatol 1998; 37: 1295-1298
- 34 Lora V, Cerroni L, Cota C. Skin manifestations of rheumatoid arthritis. G Ital Dermatol Venereol 2018; 153: 243-255
- 35 Bywaters EG, Scott JT. The Natural History of Vascular Lesions in Rheumatoid Arthritis. J Chronic Dis 1963; 16: 905-914
- 36 Sayah A, English JC. Rheumatoid arthritis: a review of the cutaneous manifestations. J Am Acad Dermatol 2005; 53: 191-209 quiz 210-2
- 37 Sanchez NP, Winkelmann RK, Schroeter AL. et al. The clinical and histopathologic spectrums of urticarial vasculitis: study of forty cases. J Am Acad Dermatol 1982; 7: 599-605
- 38 Mehregan DR, Hall MJ, Gibson LE. Urticarial vasculitis: a histopathologic and clinical review of 72 cases. J Am Acad Dermatol 1992; 26: 441-448
- 39 Kuhn A, Schuppe HC, Ruzicka T. et al. Rare cutaneous manifestaions of lupus erythematosus. A clinical overview. Hautarzt 2000; 51: 818-825
- 40 Kittridge A, Routhouska SB, Korman NJ. Dermatologic manifestations of Sjögren syndrome. J Cutan Med Surg 2011; 15: 8-14
- 41 Koh JH, Park Y, Lee J. et al. Hypergammaglobulinaemia predicts glandular and extra-glandular damage in primary Sjögren’s syndrome: results from the KISS cohort study. Clin Exp Rheumatol 2021; 39: 114-122
- 42 Lawley TJ, Moutsopoulos HM, Katz SI. et al. Demonstration of circulating immune complexes in Sjögren’s syndrome. J Immunol 1979; 123: 1382-1387
- 43 Sunderkötter C, Michl C. Cutaneous alterations in vasculitides: Part 2: Special aspects of diseases of large, medium and small vessels. Internist (Berl) 2019; 60: 805-813
- 44 Mitschang C, Görge T. Purpura pigmentosa progressiva. Phlebologie 2017; 46: 358-360
- 45 Sherertz EF. Pigmented purpuric eruptions. Semin Thromb Hemost 1984; 10: 190-195
- 46 Sardana K, Sarkar R, Sehgal VN. Pigmented purpuric dermatoses: an overview. Int J Dermatol 2004; 43: 482-488
- 47 Iwatsuki K, Aoshima T, Tagami H. et al. Immunofluorescence study in purpura pigmentosa chronica. Acta Derm Venereol 1980; 60: 341-345
- 48 Schober SM, Peitsch WK, Bonsmann G. et al. Early treatment with rutoside and ascorbic acid is highly effective for progressive pigmented purpuric dermatosis. J Dtsch Dermatol Ges 2014; 12: 1112-1119
- 49 Laufer F. The treatment of progressive pigmented purpura with ascorbic acid and a bioflavonoid rutoside. J Drugs Dermatol 2006; 5: 290-293
- 50 Weishaupt C, Strölin A, Kahle B. et al. Characteristics, risk factors and treatment reality in livedoid vasculopathy - a multicentre analysis. J Eur Acad Dermatol Venereol 2019; 33: 1784-1791
- 51 Schiffmann M-L, Dissemond J, Erfurt-Berge C. et al. S1-Leitlinie Diagnostik und Therapie der Livedovaskulopathie. J Dtsch Dermatol Ges 2021; 19: 1667-1678
- 52 Weishaupt C, Strölin A, Kahle B. et al. Anticoagulation with rivaroxaban for livedoid vasculopathy (RILIVA): a multicentre, single-arm, open-label, phase 2a, proof-of-concept trial. Lancet Haematol 2016; 3: e72-e79
- 53 Baker WFJR, Bick RL. The clinical spectrum of antiphospholipid syndrome. Hematol Oncol Clin North Am 2008; 22: 33-52 v-vi.
- 54 Gkogkolou P, Ehrchen J, Goerge T. Severe antiphospholipid antibody syndrome - response to plasmapheresis and rituximab. J Dermatolog Treat 2017; 28: 564-566
- 55 Francès C, Niang S, Laffitte E. et al. Dermatologic manifestations of the antiphospholipid syndrome: two hundred consecutive cases. Arthritis Rheum 2005; 52: 1785-1793
- 56 Crome CR, Rajagopalan S, Kuhan G. et al. Antiphospholipid syndrome presenting with acute digital ischaemia, avascular necrosis of the femoral head and superior mesenteric artery thrombus. BMJ Case Rep 2012; 2012
- 57 Cervera R, Tektonidou MG, Espinosa G. et al. Task Force on Catastrophic Antiphospholipid Syndrome (APS) and Non-criteria APS Manifestations (II): thrombocytopenia and skin manifestations. Lupus 2011; 20: 174-181