Rhodium-Catalyzed Ring Expansion and Ring Opening of ­Azetidines: Domino Conjugate Addition/Inert-Bond Activation

Abstract

Domino conjugate addition/inert-bond activation is a useful strategy for improving the efficiency of synthesis. We summarize reports on domino conjugate addition/inert-bond activation and its applications in the rhodium-catalyzed ring-expansion and ring-opening reactions of azetidines.

1 Introduction

2 Rhodium-Catalyzed Domino Conjugate Addition/β-C Cleavage/ Protonation

3 Rhodium-Catalyzed Domino Conjugate Addition/N-Directed α-C(sp³)–H Activation

4 Conclusion

Key words

conjugate addition - ring opening - ring expansion - ­transition-metal catalysis - inert-bond activation - azetidines

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