Download PDF
CC BY 4.0 · European J Pediatr Surg Rep. 2022; 10(01): e148-e151
DOI: 10.1055/a-1926-2053
Case Report

A Case of Prepubertal Ovarian Tissue Cryopreservation in Metachronous Bilateral Mature Ovarian Teratoma Requiring Bilateral Oophorectomy

Tom Malik
1   Department of Paediatric Surgery and Urology, Southampton Children's Hospital, Southampton, United Kingdom
,
Robert Wheeler
2   Department of Paediatric Surgery, Southampton Children's Hospital, Southampton, United Kingdom
,
Nigel J. Hall
3   Faculty of Medicine, University of Southampton, Southampton, United Kingdom
,
Juliet Gray
4   Centre for Cancer Immunology, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
› Author Affiliations
› Further Information
Also available at
   Permissions and Reprints

Abstract

Mature ovarian teratoma has the potential to occur metachronously in the contralateral ovary. There are significant implications for fertility as bilateral oophorectomy may be indicated. In prepubertal girls, ovarian tissue cryopreservation (OTC) offers the only possibility of a future biological pregnancy but outcome data are limited. We present a case of prepubertal OTC in a 12-year-old girl undergoing a second oophorectomy for metachronous contralateral mature teratoma. We offer a discussion of the challenges that emerged regarding perioperative decision-making, balancing the need for safe oncological resection with the desire to preserve fertility.

Keywords

mature teratoma - dermoid cyst - ovarian tumor - ovarian tissue cryopreservation - fertility


Publication History

Received: 30 January 2022

Accepted: 10 July 2022

Accepted Manuscript online:
17 August 2022

Article published online:
11 November 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Zhang M, Jiang W, Li G, Xu C. Ovarian masses in children and adolescents - an analysis of 521 clinical cases. J Pediatr Adolesc Gynecol 2014; 27 (03) e73-e77
    CrossrefPubMedGoogle Scholar
  • 2 Lala SV, Strubel N. Ovarian neoplasms of childhood. Pediatr Radiol 2019; 49 (11) 1463-1475
    CrossrefPubMedGoogle Scholar
  • 3 Children's Cancer and Leukaemia Group. Interim Guidelines for the Treatment of Extracranial Germ Cell Tumours in Children and Adolescents. Leicester: Children's Cancer and Leukaemia Group; 2018
    Google Scholar
  • 4 Braungart S, Craigie RJ, Farrelly P, Losty PD, Losty P. CCLG Surgeons Collaborators. Ovarian tumors in children: how common are lesion recurrence and metachronous disease? A UK CCLG Surgeons Cancer Group nationwide study. J Pediatr Surg 2020; 55 (10) 2026-2029
    CrossrefPubMedGoogle Scholar
  • 5 Chabaud-Williamson M, Netchine I, Fasola S. et al. Ovarian-sparing surgery for ovarian teratoma in children. Pediatr Blood Cancer 2011; 57 (03) 429-434 DOI: 10.1002/pbc.
    CrossrefPubMedGoogle Scholar
  • 6 Taskinen S, Urtane A, Fagerholm R, Lohi J, Taskinen M. Metachronous benign ovarian tumors are not uncommon in children. J Pediatr Surg 2014; 49 (04) 543-545
    CrossrefPubMedGoogle Scholar
  • 7 Carachi R, Grosfeld JL. The Surgery of Childhood Tumours. 3rd ed. In Carachi R, Grosfeld JL. eds. Berlin/Heidelberg: Springer; 2016
    CrossrefGoogle Scholar
  • 8 National Institute for Health and Care Excellence. Cancer Services for Children and Young People. London: National Institute for Health and Care Excellence; 2014
    Google Scholar
  • 9 Donnez J, Dolmans M-M. Fertility preservation in women. N Engl J Med 2017; 377 (17) 1657-1665
    CrossrefPubMedGoogle Scholar
  • 10 Losty PD. Evidence-based paediatric surgical oncology. Semin Pediatr Surg 2016; 25 (05) 333-335
    CrossrefPubMedGoogle Scholar
  • 11 Özcan R, Kuruoğlu S, Dervişoğlu S, Eliçevik M, Emir H, Büyükünal C. Ovary-sparing surgery for teratomas in children. Pediatr Surg Int 2013; 29 (03) 233-237
    CrossrefPubMedGoogle Scholar
  • 12 Demeestere I, Simon P, Dedeken L. et al. Live birth after autograft of ovarian tissue cryopreserved during childhood. Hum Reprod 2015; 30 (09) 2107-2109
    CrossrefPubMedGoogle Scholar
  • 13 Matthews SJ, Picton H, Ernst E, Andersen CY. Successful pregnancy in a woman previously suffering from β-thalassemia following transplantation of ovarian tissue cryopreserved before puberty. Minerva Ginecol 2018; 70 (04) 432-435
    PubMedGoogle Scholar
  • 14 Ernst E, Kjærsgaard M, Birkebæk NH, Clausen N, Andersen CY. Case report: stimulation of puberty in a girl with chemo- and radiation therapy induced ovarian failure by transplantation of a small part of her frozen/thawed ovarian tissue. Eur J Cancer 2013; 49 (04) 911-914
    CrossrefPubMedGoogle Scholar
  • 15 Poirot C, Abirached F, Prades M, Coussieu C, Bernaudin F, Piver P. Induction of puberty by autograft of cryopreserved ovarian tissue. Lancet 2012; 379 (9815): 588
    CrossrefPubMedGoogle Scholar
  • 16 CCLG Late Effects Group. Oncofertility Consensus Document. Leicester: Children's Cancer and Leukaemia Group; 2019
    Google Scholar