Potassium Persulfate/Tributylamine-Mediated Alkylation/Annulation of N-Arylacrylamides with Alkyl Iodides

Abstract

We report a catalyst-free method for the alkylation/annulation of N-arylacrylamides to give the corresponding 3-alkyl-2-oxo-2,3-dihydro-1H-indoles by using alkyl iodides as precursors of alkyl radicals. These reactions occur at moderate temperatures and are mediated by easily accessible K₂S₂O₈ and Bu₃N.

Key words

arylacrylamides - cyclization - oxindoles - halogen-atom transfer - alkylation

Publikationsverlauf

Eingereicht: 23. Juli 2022

Angenommen nach Revision: 06. September 2022

Accepted Manuscript online:
06. September 2022

Artikel online veröffentlicht:
17. Oktober 2022

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