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Synlett 2022; 33(20): 2009-2012
DOI: 10.1055/a-1938-0643
DOI: 10.1055/a-1938-0643
letter
Transition-Metal-Free Synthesis of 3-Ethynylcoumarins by a DBU-Promoted Intramolecular Morita–Baylis–Hillman-Type Reaction/Dehydration/Isomerization Cascade
We thank the Natural Science Foundation of Zhejiang Province (Grant LTZ22B020002 and Grant LY20B020012) and Fundamental Research Funds for the Central Universities (2022CDJXY-025) for their financial support of this work.
Abstract
A transition-metal-free synthesis of 3-ethynylcoumarins from salicylaldehyde-derived alkynoates was developed involving a DBU-promoted intramolecular Morita–Baylis–Hillman-type reaction/dehydration/isomerization cascade. A wide variety of alkynoates were employed to deliver 3-ethynylcoumarins in moderate to good yields.
Key words
transition-metal-free reaction - ethynylcoumarins - Morita–Baylis–Hillman reaction - step economy - cascade reactionSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1938-0643.
- Supporting Information
Publication History
Received: 02 August 2022
Accepted after revision: 07 September 2022
Accepted Manuscript online:
07 September 2022
Article published online:
17 October 2022
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