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DOI: 10.1055/a-1942-6969
Total Synthesis of Marine-Derived Azole Resistant Antifungal Agent (–)-Melearoride A and Antibiotic (–)-PF1163B
Y.B. thanks the University Grants Commission, New Delhi, India for financial assistance in the form of a Fellowship.
IICT Communication no. IICT/Pubs./2022/207
Abstract
A flexible stereoselective and convergent cum divergent approach to the synthesis of two 13-membered macrolides through a common skeleton present in their structure is described featuring two different routes, with good overall yield. The key synthetic reactions utilized include Keck allylation, Evans asymmetric methylation, Grubbs metathesis, and Julia–Kocienski olefination.
Key words
macrolides - melearoride A - PF1163B - Julia–Kocienski olefination - ring-closing metathesisSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1942-6969.
- Supporting Information
Publikationsverlauf
Eingereicht: 10. August 2022
Angenommen nach Revision: 07. September 2022
Accepted Manuscript online:
14. September 2022
Artikel online veröffentlicht:
12. Oktober 2022
© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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