Thromboinflammation: Dynamik physiologischer und pathologischer Wechselwirkungen von Entzündung und Koagulation

Zusammenfassung

Das konzertante Zusammenspiel zwischen endothelialer Dysfuntion, aktivierten Thrombozyten und anderen Immunzellen sowie simultaner Komplementaktivierung führt zur Aktivierung und gegenseitigen Verstärkung sowohl der Immunantwort als auch der Gerinnungskaskade. Durch die unkontrollierte Fortdauer dieser physiologischen Mechanismen kann der pathologische Prozess der Thromboinflammation induziert werden. In dieser Übersichtsarbeit fassen wir grundlegende Mechanismen zusammen, die zur Thromboinflammation als ein Auslöser von venösen Thromboembolien führen.

Abstract

The orchestral interaction between endothelial dysfunction, activated thrombocytes and other immune cells as well as the concomitant activation of complement lead to simultaneous activation of the immune system and coagulation. An uncontrolled persistence of these physiological mechanisms can induce pathological processes of thromboinflammation. This review article aims to summarise mechanisms leading to thromboinflammation as a cause of venous thromboembolism.

Schlüsselwörter

Entzündung - Gerinnung - Thromboinflammation - Autoimmunität - COVID19

Key words

inflammation - coagulation - thromboinflammation - autoimmunity - COVID-19online publiziert 2022

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