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Synthesis 2023; 55(03): 481-488
DOI: 10.1055/a-1954-4920
DOI: 10.1055/a-1954-4920
paper
Rhodium(III)-Catalyzed Intramolecular Benzylic C(sp3)–H Amidation for the Synthesis of Isoindolinones
This work was supported by the Shandong Provincial Natural Science Foundation, China (ZR2020MB006 and ZR2016JL009) and the University of Jinan.
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Abstract
The synthesis of N-unprotected isoindolinones via rhodium(III)-catalyzed intramolecular C(sp3)–H amidation of various 2-methyl-N-substituted benzamides is developed. This protocol employs a free amino acid l-alanine as a ligand, which could significantly increase the reactivity of rhodium catalyst.
Key words
rhodium(III) catalyst - C(sp3)–H amidation - isoindolinones - N-substituted benzamides - synthetic methodsSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1954-4920.
- Supporting Information
Publication History
Received: 23 August 2022
Accepted after revision: 04 October 2022
Accepted Manuscript online:
04 October 2022
Article published online:
10 November 2022
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