Synthesis, Inhaltsverzeichnis Synthesis 2023; 55(11): 1724-1735DOI: 10.1055/a-1970-4452 paper Special Issue dedicated to Prof. Cristina Nevado, recipient of the 2021 Dr. Margaret Faul Women in Chemistry Award N-Fluorenyltryptamines as a Useful Platform for Catalytic Enantioselective Pictet–Spengler Reactions Alafate Adili‡ , Aniket V. Sole‡ , Bishwaprava Das , Megan E. Matter , Daniel Seidel ∗ Artikel empfehlen Abstract Artikel einzeln kaufen Alle Artikel dieser Rubrik Abstract In the presence of a thiourea–carboxylic acid catalyst, N-9-fluorenyltryptamines undergo highly enantioselective Pictet–Spengler reactions with a range of aldehydes. The reaction works particularly well with aromatic aldehydes, tolerating electronically diverse substituents in all ring positions. Electron-deficient tryptamines are viable substrates. Removal of the fluorenyl protecting group is readily accomplished without deterioration of product ee. 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Ed. 2013; 52: 11569 11 The synthesis of 2p at room temperature was complete within 30 minutes, providing the product in 95% yield and with 80% ee. Zusatzmaterial Zusatzmaterial Supporting Information
