B-Cell-Maturation-Antigen (BCMA) als Target in der Myelomtherapie

Das Multiple Myelom ist durch wiederkehrende Rezidive und eine progrediente Therapierefraktärität gekennzeichnet. Neuartige Immuntherapien wie CAR-T-Zellen und bispezifische Antikörper werden die Behandlungslandschaft des Multiplen Myeloms revolutionieren. Die Effektivität und das Sicherheitsprofil dieser Therapien sind jedoch von der Spezifität der Zielstruktur abhängig. BCMA als therapeutischer Angriffspunkt stellt eine vielversprechende Option dar.

Schlüsselwörter

Multiples Myelom - BCMA - Antikörper-Wirkstoff-Konjugate - CAR-T-Zellen - bispezifische Antikörper

• Literatur

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