TBHP/KI-Promoted Oxidative Cyclization of α-Aminoketones for One-Pot Synthesis of Substituted 2-Acyloxazoles

Jiecheng Zheng; Dali Zhu; Zhangyou Yang; Huali Chen; Wei Wang; Lin Ling Gan; Zongjie Gan

doi:10.1055/a-1996-8388

Synthesis, Table of Contents

Synthesis 2023; 55(09): 1419-1426
DOI: 10.1055/a-1996-8388

paper

TBHP/KI-Promoted Oxidative Cyclization of α-Aminoketones for One-Pot Synthesis of Substituted 2-Acyloxazoles

Jiecheng Zheng‡

^aDepartment of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, P. R. of China

,

Dali Zhu‡

^aDepartment of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, P. R. of China

,

Zhangyou Yang

^aDepartment of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, P. R. of China

,

Huali Chen

^aDepartment of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, P. R. of China

,

Wei Wang

^bChongqing Fuling Institute for Food and Drug Control, Chongqing 408102, P. R. of China

,

Lin Ling Gan∗

^cChongqing Engineering Research Center of Pharmaceutical Sciences, School of Pharmacy, Chongqing Medical and Pharmaceutical College, Chongqing 401331, P. R. of China

,

Zongjie Gan ∗

^aDepartment of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, P. R. of China

› Author Affiliations

Abstract

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Abstract

A metal-free and facile synthesis of substituted 2-acyloxazole derivatives from α-aminoketones was developed via a TBHP/KI-promoted oxidative cyclization. This procedure proceeded smoothly under mild conditions and a broad scope of 2-acyloxazoles were obtained in moderate to good yields.

Key words

metal-free - TBHP/KI - 2-acyloxazole - oxidative cyclization

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References

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