TBHP/KI-Promoted Oxidative Cyclization of α-Aminoketones for One-Pot Synthesis of Substituted 2-Acyloxazoles

Abstract

A metal-free and facile synthesis of substituted 2-acyloxazole derivatives from α-aminoketones was developed via a TBHP/KI-promoted oxidative cyclization. This procedure proceeded smoothly under mild conditions and a broad scope of 2-acyloxazoles were obtained in moderate to good yields.

Key words

metal-free - TBHP/KI - 2-acyloxazole - oxidative cyclization

Publication History

Received: 14 October 2022

Accepted after revision: 12 December 2022

Accepted Manuscript online:
12 December 2022

Article published online:
05 January 2023

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