TBHP/KI-Promoted Oxidative Cyclization of α-Aminoketones for One-Pot Synthesis of Substituted 2-Acyloxazoles
Jiecheng Zheng‡
a
Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, P. R. of China
,
Dali Zhu‡
a
Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, P. R. of China
,
Zhangyou Yang
a
Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, P. R. of China
,
Huali Chen
a
Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, P. R. of China
,
Wei Wang
b
Chongqing Fuling Institute for Food and Drug Control, Chongqing 408102, P. R. of China
,
Lin Ling Gan∗
c
Chongqing Engineering Research Center of Pharmaceutical Sciences, School of Pharmacy, Chongqing Medical and Pharmaceutical College, Chongqing 401331, P. R. of China
A metal-free and facile synthesis of substituted 2-acyloxazole derivatives from α-aminoketones was developed via a TBHP/KI-promoted oxidative cyclization. This procedure proceeded smoothly under mild conditions and a broad scope of 2-acyloxazoles were obtained in moderate to good yields.
14 CCDC 2220726 (2a) contains the supplementary crystallographic data for this paper. The data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/structures
15
Cao ZZ,
Lv HF,
Liu YF,
Nie ZW,
Liu HP,
Yang TL,
Luo WP,
Liu Q,
Guo CC.
Adv. Synth. Catal. 2019; 361: 1632
