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Klin Monbl Augenheilkd 2023; 240(04): 385-386
DOI: 10.1055/a-2004-5200
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Spontaneous Corneal Perforation in Treatment-Resistant MPO-ANCA-Associated Small Vessel Vasculitis

Spontane Hornhautperforation bei therapieresistenter MPO-ANCA-assoziierter Kleingefässvaskulitis
Karin Zehnder
Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
,
Aja Reinhold
Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
,
Konstantin Gugleta
Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
,
Zisis Gatzioufas
Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
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Background

Spontaneous corneal perforation is a rare complication in sterile ulcerative keratitis [1]. Identifying the systemic causes is essential for optimal treatment. Anti-myeloperoxidase antibodies (MPO) are a subcategory of perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA). MPO-ANCA-associated small vessel vasculitis is a potential cause of sterile ulcerative keratitis. Being an autoimmune disorder, immunosuppressive therapy is indicated. Besides steroids, biologicals such as rituximab can be used with excellent results [2], [3].

We hereby report on an 83-year-old male patient with MPO-ANCA-positive small vessel vasculitis who developed a spontaneous corneal perforation despite immunosuppressive therapy.



Publication History

Received: 26 September 2022

Accepted: 09 December 2022

Article published online:
25 April 2023

© 2023. Thieme. All rights reserved.

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