Copper-Catalyzed Radical Cascade Annulation for the Preparation of Difluorinated Pyrrolidines and Piperidines

Michela Maria Marchese; Sebastian Strähler; Lucian Ghiba; Olivier Riant

doi:10.1055/a-2004-6031

Synthesis, Table of Contents

Synthesis 2023; 55(12): 1886-1892
DOI: 10.1055/a-2004-6031

paper

Special Issue dedicated to Prof. Alain Krief

Copper-Catalyzed Radical Cascade Annulation for the Preparation of Difluorinated Pyrrolidines and Piperidines

Michela Maria Marchese

,

Sebastian Strähler

,

Lucian Ghiba

,

Olivier Riant ∗

Abstract

All articles of this category

This article is dedicated to Professor Alain Krief on the occasion of his 80^th birthday

Abstract

In this work, we developed a one-pot, copper-catalyzed aminodifluoroalkylation of enylaniline derivatives. This approach allows the catalytic construction of a broad range of pyrrolidines and piperidines substituted with a gem-difluoro moiety.

Key words

pyrrolidine - piperidine - heterocycles - copper - fluorine - catalysis

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