Copper-Catalyzed Radical Cascade Annulation for the Preparation of Difluorinated Pyrrolidines and Piperidines

This article is dedicated to Professor Alain Krief on the occasion of his 80^th birthday

Abstract

In this work, we developed a one-pot, copper-catalyzed aminodifluoroalkylation of enylaniline derivatives. This approach allows the catalytic construction of a broad range of pyrrolidines and piperidines substituted with a gem-difluoro moiety.

Key words

pyrrolidine - piperidine - heterocycles - copper - fluorine - catalysis

Publication History

Received: 16 November 2022

Accepted after revision: 29 December 2022

Accepted Manuscript online:
29 December 2022

Article published online:
02 February 2023

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