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DOI: 10.1055/a-2010-7874
The Untold Journey of Total Synthesis of Natural Products
This research was financially supported by the Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) (SMSEGL20Sc01-B), and Research Grant Council of Hong Kong (C6026-19G, 16307219, 16306920, and 16300921).
Abstract
This personal Account presents the developments of two synthetic strategies (Phenol Oxidative Dearomatization, POD; and Furan Oxidative dearomatization, FOD) for total synthesis of natural products. The POD program was originally derived from our first total synthesis of tenuipyrone, while our productive FOD program arose from the total synthesis of the uprolide family. Instead of a review summary of our total synthesis, this Account is focused on how these total synthesis projects are conceived and connected from the perspective of laboratory development. It is evident that total synthesis is not an isolated event, but a connecting and inspirational point that sparks new ideas and new projects.
1 Introduction
2 Total Synthesis versus Synthetic Methodology
3 Development of Phenol Oxidative Dearomatization (POD) for Total Synthesis
4 Development of Furan Oxidative Dearomatization (FOD, Achmatowicz rearrangement) for Total Synthesis
5 Conclusion and Outlook
Key words
total synthesis - natural product - dearomatization - Achmatowicz rearrangement - o-quinone methidePublikationsverlauf
Eingereicht: 30. Dezember 2022
Angenommen: 11. Januar 2023
Accepted Manuscript online:
11. Januar 2023
Artikel online veröffentlicht:
15. Februar 2023
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