Recent Advances on the Carboxylations of C(sp³)–H Bonds Using CO₂ as the Carbon Source

Dedicated to Prof. Masahiro Murakami for his unparalleled contributions on the topic of CO₂ utilization in organic synthesis.

Abstract

Carbon dioxide (CO₂) is widely known as being a sustainable C1 synthon for the synthesis of various carboxylic acid derivatives, including essential natural and unnatural amino acids. While it is sustainable, the high thermodynamic stability and kinetic inertness of the CO₂ molecule is a major drawback to its wider use in organic synthesis. However, the reduction of this inert and highly stable CO₂ molecule has been carried out successfully over the past few years using various stoichiometric as well as catalytic approaches. Initially, chemists employed transition-metal/transition-metal-free thermochemical methods for the incorporation of CO₂ into organic compounds, however, gradually, the introduction of greener approaches such as visible-light-induced photoredox catalysis and electrocatalysis became revolutionary for the synthesis of carboxylic acids under mild reaction conditions. In this short review, we discuss the recent advances in carboxylation reactions via functionalization of the (sp³)C–H bonds of various organic molecules with CO₂ using thermochemical, photochemical and electrochemical methods.

1 Introduction

2 Transition-Metal/Transition-Metal-Free Thermochemical Carbox ylations of C(sp³)–H Bonds

2.1 C(sp³)–H Bond Carboxylation of Carbonyls

2.2 Allylic, Benzylic and Alkyl C(sp³)–H Bond Carboxylation

3 Photochemical C(sp³)–H Bond Carboxylation

3.1 Allylic C(sp³)–H Bond Carboxylation

3.2 Benzylic C(sp³)–H Bond Carboxylation

4 Electrochemical Carboxylation of C(sp³)–H Bonds

5 Conclusion and Outlook

Key words

carbon dioxide - transition-metal - transition-metal-free - thermochemical strategy - visible-light-induced photocatalysis - electrocatalysis - reductive C–H carboxylations - carboxylic acids

Publication History

Received: 15 December 2022

Accepted after revision: 13 January 2023

Accepted Manuscript online:
13 January 2023

Article published online:
16 February 2023

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