Synthesis, Table of Contents Synthesis 2023; 55(15): 2343-2352DOI: 10.1055/a-2022-1511 paper Special Issue dedicated to Prof. David A. Evans Synthesis of Polycyclic Imidazoles via α-C–H/N–H Annulation of Alicyclic Amines Subhradeep Dutta‡ , Kamal Bhatt‡ , Fabian Cuffel , Daniel Seidel ∗ Recommend Article Abstract Buy Article All articles of this category Abstract Secondary alicyclic amines are converted into their corresponding ring-fused imidazoles in a simple procedure consisting of oxidative imine formation followed by a van Leusen reaction. Amines with an existing α-substituent undergo regioselective ring-fusion at the α′-position. This method was utilized in a synthesis of fadrozole. Key words Key wordsC–H bond functionalization - amines - annulation - imidazoles - heterocycles Full Text References References Selected reviews on the relevance of azacycles in medicine: 1a Taylor RD, MacCoss M, Lawson AD. G. J. Med. Chem. 2014; 57: 5845 1b Vitaku E, Smith DT, Njardarson JT. J. Med. 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