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Synthesis 2023; 55(12): 1875-1885
DOI: 10.1055/a-2039-5229
DOI: 10.1055/a-2039-5229
paper
Photo-Induced Selective Difluoroalkylation of Unactivated Alkenes to Access Difluoroalkylated Indoles
The authors thank the National Natural Science Foundation of China (21961002, 22161004) for financial support. This work was also financially supported by Gannan Medical University (QD202019, QD202106, TD2021YX05-2).
Abstract
The difluoroalkylation of unactivated alkenes with ethyl iododifluoroacetate via visible light-induced process has been developed. This transformation provides selective access to difluoroalkylated indole derivatives in good yields depending on the choice of base, solvent, as well as the loading of ethyl iododifluoroacetate.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2039-5229.
- Supporting Information
Publikationsverlauf
Eingereicht: 10. Januar 2023
Angenommen nach Revision: 21. Februar 2023
Accepted Manuscript online:
21. Februar 2023
Artikel online veröffentlicht:
29. März 2023
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