Synthesis 2023; 55(14): 2253-2260
DOI: 10.1055/a-2042-3533
paper
Special Issue Honoring Prof. Guoqiang Lin’s Contributions to Organic Chemistry

One-Pot Iron-Catalyzed Cross-Coupling Reactions of Aryl Chlorides and Aryl Bromides

Yi-Bing Yin
a   Department of Chemistry, and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, P. R. of China
,
Xiao-Shui Peng  ∗
a   Department of Chemistry, and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, P. R. of China
b   School of Science and Engineering, Shenzhen Key Laboratory of Innovative Drug Synthesis, The Chinese University of Hong Kong (Shenzhen), Longgang District, Shenzhen, P. R. of China
,
Henry N. C. Wong∗
a   Department of Chemistry, and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, P. R. of China
b   School of Science and Engineering, Shenzhen Key Laboratory of Innovative Drug Synthesis, The Chinese University of Hong Kong (Shenzhen), Longgang District, Shenzhen, P. R. of China
› Author AffiliationsThis work was supported by grants from the National Natural Science Foundation of China (NSFC) (22271243, 21971219), Guangdong Innovative and Entrepreneurial Research Team Program, Leading Talents Program of Guangdong Province, Shenzhen Science and Technology Innovation Committee for the Shenzhen Key Laboratory Fund, Research Grants Council (Hong Kong) (GRF CUHK14304819), and Innovation and Technology Commission (Hong Kong) in the form of a subsidy to the State Key Laboratory of Synthetic Chemistry, and by University Development Fund Grants from The Chinese University of Hong Kong, Shenzhen.
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Abstract

A one-pot iron-catalyzed cross-coupling protocol involving aryl chlorides, aryl bromides and magnesium metal was developed towards the construction of unsymmetrical biaryls. The key procedure of this reaction is the in situ generation of Grignard reagents.

Key words

iron-catalyzed - cross-coupling - one-pot reaction - aryl chlorides - aryl bromides

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/a-2042-3533.
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Publication History

Received: 01 February 2023

Accepted after revision: 24 February 2023

Accepted Manuscript online:
24 February 2023

Article published online:
06 April 2023

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