Synthesis of 2,2′-Bipyridines via Dehydrogenative Dimerization of Pyridines Using Sodium Dispersion

Dedicated to Professor Shigeru Yamago on the occasion of his 60^th birthday

Abstract

2,2′-Bipyridine derivatives were synthesized by dehydrogenative dimerization of nonactivated pyridines using sodium dispersion. The reaction features operational simplicity, mild conditions, and the use of earth abundant and nontoxic sodium as the sole metal source. Importantly, transition metals are not required, which is beneficial in the fields of materials science and drug synthesis, where the contamination of the transition metals may cause significant problems.

Key words

2,2′-bipyridine - sodium dispersion - dehydrogenative coupling - transition-metal-free - sustainable chemistry

Publication History

Received: 05 February 2023

Accepted after revision: 06 March 2023

Accepted Manuscript online:
06 March 2023

Article published online:
17 April 2023

• References and Notes

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