Use of Carbonyldiimidazole as an Activator of Formic Acid in a Tris(dibenzylideneacetone)dipalladium-Catalyzed Formylation of Aryl Iodides

Abstract

A carbonyldiimidazole (CDI)-promoted generation of CO from formic acid has been exploited in a reductive formylation of aryl iodides in the presence of tris(dibenzylideneacetone)dipalladium. The reaction conditions are mild with a broad functional-group tolerance that includes keto, bromo, nitrile, ester, and nitro groups. In the reaction pathway, CDI reacts with formic acid to generate a formyl imidazole that ultimately produces the CO needed for the formylation process on the activated arylpalladium complex.

Key words

formylation - carbonyldiimidazole - formic acid - palladium catalysis - aryl aldehydes - aryl iodides

Publikationsverlauf

Eingereicht: 02. Dezember 2022

Angenommen nach Revision: 06. März 2023

Accepted Manuscript online:
06. März 2023

Artikel online veröffentlicht:
12. April 2023

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