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Synthesis 2024; 56(06): 890-905
DOI: 10.1055/a-2066-1659
DOI: 10.1055/a-2066-1659
review
Emerging Trends in Glycoscience
Recent Advances in the Synthesis and Application of C-2-Formyl Glycals
We are appreciative to the Institute of Eminence at the University of Delhi for helping to strengthen research and development through financial support. The Council of Scientific and Industrial Research (CSIR), New Delhi, India, has awarded Sumit Kumar and Aditi Arora a Junior Research Fellowship (JRF) and they are grateful to CSIR.
Abstract
C-2-Formyl glycals have sustained interest in carbohydrate chemistry as they afford valuable chiral building blocks for many biological-, pharmaceutical-, and industrial-based important molecules. Basically, C-2-formyl glycals are a class of carbohydrates incorporating an α,β-unsaturated aldehyde. Therefore in many organic reactions, the C-2-formyl glycals can serve as an α,β-unsaturated aldehyde core. In this review, we have compiled a literature survey covering the period 2013–2022, on the synthesis of C-2-formyl glycals and further discuss their importance for the synthesis of many medicinal, supramolecular, biological, organic, and material chemistry based molecules.
1 Introduction
2 Synthesis of C-2-Formyl Glycals
2.1 Vilsmeier–Haack Formylation
2.2 By Consecutive Cyclization
2.3 XtalFluor‑E Based Synthesis
3 Applications of C-2-Formyl Glycals
3.1 C-2-Formyl Glycals as a Synthons
3.2 Anticancer
3.3 Anti-inflammatory
3.4 Antimicrobial
3.5 Glycosidase Inhibitors
3.6 Miscellaneous
4 Conclusion and Future Aspects
Key words
C-2-formyl glycals - α,β-unsaturated aldehyde - carbohydrate - Vilsmeier–Haack reaction - biological activity - glycosidesPublication History
Received: 21 February 2023
Accepted after revision: 30 March 2023
Accepted Manuscript online:
30 March 2023
Article published online:
02 May 2023
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