Synthesis 2023; 55(17): 2683-2690
Cu(OTf)2 /TBHP/O2 -Mediated Tandem Oxidative Reaction: Easy Access to Benzopyrano[4,3-b ]pyridines
Dongping Cheng∗
a
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. of China
,
Hongjiao Yang
a
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. of China
,
Hongshuang Xia
a
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. of China
,
Huafang Gu
a
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. of China
,
Jing-Hua Li∗
a
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. of China
,
Xiaoliang Xu∗
b
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. of China
› Institutsangaben This work was supported by the National Natural Science Foundation of China (22078300).
Abstract
An effective tandem reaction of 4-aminocoumarins and 1,3-diarylpropenes mediated by Cu(OTf)2 /TBHP (tert -butyl hydroperoxide)/O2 that provides various benzopyrano[4,3-b ]pyridines in moderate to good yields is disclosed. The reaction proceeds through oxidative coupling, intramolecular cyclization, and dehydro-aromatization. This approach has the advantages of high atom-economy, environmental compatibility, and wide substrate scope.
Key words
tandem reaction -
oxidative coupling -
TBHP -
4-aminocoumarin -
benzopyrano[4,3-
b ]pyridines
Supporting Information
Supporting information for this article is available online at https://doi.org/10.1055/a-2067-4099.
Supporting Information
Publikationsverlauf
Eingereicht: 07. Februar 2023
© 2023. Thieme. All rights reserved
Georg Thieme Verlag KG
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