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Synlett 2024; 35(01): 21-28
DOI: 10.1055/a-2071-4549
DOI: 10.1055/a-2071-4549
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Functional Dyes
Near-Infrared Hemicyanine Fluorophores with Optically Tunable Groups: A ‘Leap Forward’ for in Vivo Sensing and Imaging
We would like to thank the Natural Science Foundation of Hunan Province (2021JJ30073) (J.W.), and the National Natural Science Foundation of China (NSFC) (22074036) (L.Y.).
Abstract
Hemicyanine dyes, with a tunable optical site and high wavelength tailorability, are of significant importance in the fields of sensing and diagnosis. Following the discovery of the near-infrared (NIR) (650–900 nm) fluorescent dyes Changsha (CS) and Huda (HD) by our group, remarkable progress has been made in the development of hemicyanine-based probes for in vivo imaging and detecting. In this review, we summarize the key contributions made by our group in developing long-wavelength (650–1700 nm) hemicyanines and utilizing them to construct functional probes. Finally, potential drawbacks and future prospects of hemicyanine dyes/probes are discussed.
1 Introduction
2 Changsha (CS) Dyes
3 Huda (HD) Dyes
4 Construction of Hemicyanine Fluorophores in the NIR-II Region
5 Summary and Outlook
Publication History
Received: 13 March 2023
Accepted after revision: 11 April 2023
Accepted Manuscript online:
11 April 2023
Article published online:
01 June 2023
© 2023. Thieme. All rights reserved
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