A Sulfoxide Reagent for Sulfinylative Cross-Coupling

Abstract

I recently documented the strategic use of a sulfoxide reagent as a sulfur monoxide equivalent to enable one-pot, three-component syntheses of sulfoxides and sulfinamides. The sulfoxide reagent donates the SO unit upon the reaction with Grignard reagents (RMgX) as sulfenate anions (RSO^–). The anionic sulfur intermediates can be readily transformed into sulfoxides and sulfinamides via trapping with appropriate carbon and nitrogen electrophiles. This Synpacts article highlights my first efforts to establish a general sulfinylative cross-coupling platform.

1 Introduction

2 Development of a Sulfoxide Reagent as a Sulfur Monoxide Equivalent

3 Conclusions and Future Directions

Key words

sulfinylative cross-coupling - Grignard reagents - one-pot synthesis - sulfinamides - sulfoxides

Publikationsverlauf

Eingereicht: 09. April 2023

Angenommen nach Revision: 25. April 2023

Accepted Manuscript online:
25. April 2023

Artikel online veröffentlicht:
25. Mai 2023

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