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DOI: 10.1055/a-2122-4287
Improved Syntheses of an Arseno-Fatty Acid (As-FA 362) and an Arseno-Hydrocarbon (As-HC 444)
This research was supported by National Institute of Environmental Health Sciences grants R03ES033333 (to A.D., J.B., and M.F.) and R03ES034194 (to A.D. and J.B.).
Abstract
Robust and reliable synthetic methods have been developed for the preparation of an arseno-fatty acid (As-FA362) and an arseno-hydrocarbon (As-HC444). An improved route to access the starting materials necessary for the new synthetic routes is also disclosed. With these improvements, an increased accessibility to arsenic-containing compounds is anticipated, which may be deployed as standards required for the development of quantitative methods in biological matrices. For the first time, stability data for these compounds are reported. With these results in hand, data on the elimination profile, bioaccumulation potential and patho-behavioral and physiological consequences of these organoarsenicals are planned.
Publication History
Received: 30 May 2023
Accepted after revision: 03 July 2023
Accepted Manuscript online:
04 July 2023
Article published online:
17 August 2023
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