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Synthesis 2024; 56(01): 16-28
DOI: 10.1055/a-2124-3823
DOI: 10.1055/a-2124-3823
short review
Decoration on Cubane with an Awareness of Chirality: Development of Substituted Cubane Syntheses
The authors were supported for their works, shown in this review, by JSPS KAKENHI Grants 23H02605, 21H05233, JST-Project JPMJMS522362 (SM), and JSPS DC1 research fellowship 23KJ1339 (HT).
Abstract
Nearly 60 years have passed since Professor Eaton’s practical synthesis of cubane, and research using it as a unique molecular scaffold has since gained momentum. Since the early synthesis of polynitrocubane, it has been shown that up to eight substituents can be covalently assembled into a confined space. The arrangement of substituents on cubane has paved the way for the creation of unique asymmetric molecules. To put it another way, chirality is manifested by selectively introducing three or more diverse types of substituents at specific sites. Recently, there has also been a report on the synthesis of perfluorocubane, a molecule with intriguing electronic properties.
1 Introduction
2 General Information
3 Functionalization of Cubane
4 Preparation of Polysubstituted Cubanes
5 Conclusion
Publication History
Received: 26 May 2023
Accepted after revision: 06 July 2023
Accepted Manuscript online:
06 July 2023
Article published online:
31 August 2023
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