Synthesis 2024; 56(11): 1677-1686
DOI: 10.1055/a-2133-1963
feature
New Trends in Organic Synthesis from Chinese Chemists

Synthesis of β-Hydroxyhydrophosphonic Acids from Inorganic Sodium Hypophosphite

Dang-Wei Qian
a   State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, 222 South Tianshui Road, Lanzhou 730000, P. R. of China
,
Jin Yang
a   State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, 222 South Tianshui Road, Lanzhou 730000, P. R. of China
,
Gang-Wei Wang
a   State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, 222 South Tianshui Road, Lanzhou 730000, P. R. of China
,
Shang-Dong Yang
a   State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, 222 South Tianshui Road, Lanzhou 730000, P. R. of China
b   State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P. R. of China
› Institutsangaben
We are grateful to the NSFC (No. 22171119) and Gansu Province Science and Technology plan for major projects (No. 21ZD4WA021) and key research plan (No. 21YF5WA114) for financial support.


Abstract

An efficient approach to access β-hydroxyhydrophosphonic acid derivatives is reported by ring-opening reaction of readily available epoxides with green, inexpensive, and safe inorganic salt sodium hypophosphate as the phosphorus source in the presence of silver trifluoromethanesulfonate as the catalyst. The reaction is achieved under simple operation and exhibits excellent selectivity as well as good functional group compatibility.

Supporting Information



Publikationsverlauf

Eingereicht: 12. Juni 2023

Angenommen nach Revision: 19. Juli 2023

Accepted Manuscript online:
19. Juli 2023

Artikel online veröffentlicht:
13. September 2023

© 2023. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany