Recent Progress on Copper-Catalyzed C–C Bond Formation via C(sp²)–H Insertions Using Diazo and Related Compounds

Abstract

The site-selective insertion of metal carbenes via C(sp²)–H bond functionalization is an interesting topic within the synthetic chemistry community. In recent years, studies on the formation and applications of copper carbene intermediates have increased significantly due to their cost-effectiveness and versatile reactivities. Furthermore, copper-catalyzed transformations involving C(sp²)–H insertions using diazo and related compounds, along with asymmetric versions, have emerged as new tools for C–C bond formation. This short review summarizes selected recent advances in this field.

1 Introduction

2 Insertion of Copper Carbenes into Aryl C(sp²)–H Bonds of Arenes

3 Copper Carbene Insertion into Aryl C(sp²)–H Bonds of Azaheteroarenes

4 Copper Carbene Insertion into C(sp²)–H Bonds of Alkenes

5 Conclusions and Perspectives

Key words

copper catalysis - metal carbenes - C(sp²)–H insertion - C–C bond - diazo compounds

Publication History

Received: 31 May 2023

Accepted after revision: 20 July 2023

Accepted Manuscript online:
20 July 2023

Article published online:
08 September 2023

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