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Z Gastroenterol 2023; 61(11): 1518-1525
DOI: 10.1055/a-2150-2156
Mitteilungen

Positionspapier der Arbeitsgruppe Chronisch Entzündliche Darmerkrankungen der ÖGGH zum Einsatz von Vedolizumab subkutan

Use of subcutaneous Vedolizumab: A position paper issued by the Inflammatory Bowel Disease Working Group of the Austrian Society of Gastroenterology and Hepatology (ÖGGH)
Simon Reider 
1   Universitätsklinik für Innere Medizin mit Schwerpunkt Gastroenterologie und Hepatologie, Kepler Universitätsklinikum Gmbh, Johannes Kepler Universität Linz, Linz, Austria (Ringgold ID: RIN27266)
2   Christian Doppler Labor für Mukosale Immunologie, Johannes Kepler Universität Linz, Linz, Austria (Ringgold ID: RIN31197)
,
Gottfried Novacek
3   Abt. Gastroenterologie & Hepatologie, Univ.-Klinik Innere Medizin III, Vienna, Austria
,
Thomas Haas
4   Darmpraxis Salzburg, Salzburg, Austria
,
Hans-Peter Gröchenig
5   Medizinische Abteilung, Krankenhaus der Barmherzigen Brüder, St.Veit an der Glan, Austria
,
Reingard Platzer
6   1. Interne Abteilung, Landesklinikum Wiener Neustadt, Wr.Neustadt, Austria
,
Robert Koch
7   Universitätsklinik für Innere Medizin I, Medizinische Universitat Innsbruck, Innsbruck, Austria (Ringgold ID: RIN27280)
,
Patrizia Katharina Kump
8   Klinische Abteilung für Gastroenterologie und Hepatologie, Medizinische Universität Graz, Graz, Austria
,
Walter Reinisch
9   Univ.-Klinik Innere Medizin III, Vienna, Austria
,
Alexander Moschen
1   Universitätsklinik für Innere Medizin mit Schwerpunkt Gastroenterologie und Hepatologie, Kepler Universitätsklinikum Gmbh, Johannes Kepler Universität Linz, Linz, Austria (Ringgold ID: RIN27266)
2   Christian Doppler Labor für Mukosale Immunologie, Johannes Kepler Universität Linz, Linz, Austria (Ringgold ID: RIN31197)
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Zusammenfassung

Der humanisierte monoklonale anti-α4β7-Integrin-Antikörper Vedolizumab ist eine von mehreren biologischen Therapieoptionen bei moderaten und schweren Verläufen von Colitis ulcerosa und Morbus Crohn. Im Zuge des VISIBLE-Studienprogramms wurde zusätzlich zur etablierten intravenösen Verabreichung eine subkutane Administrationsform von Vedolizumab erprobt. Die Arbeitsgruppe CED der Österreichischen Gesellschaft für Gastroenterologie und Hepatologie (ÖGGH) fasst in diesem Positionspapier die Datenlage zur subkutanen Applikation von Vedolizumab zusammen, ergänzt ein bestehendes Positionspapier zum Stellenwert von Vedolizumab als Erstlinientherapie bei chronisch entzündlichen Darmerkrankungen und bietet praxisnahe Empfehlungen zur praktischen Anwendung.

Abstract

The humanized monoclonal anti-α4β7-integrin-antibody vedolizumab is one of several biologic therapeutic options in moderate-to-severe ulcerative colitis and Crohn’s disease. Within the VISIBLE trial program, a novel subcutaneous application route was evaluated in addition to the already established intravenous form. In this position statement, the working group “Inflammatory Bowel Diseases” of the Austrian Society for Gastroenterology and Hepatology (OEGGH) summarizes the evidence regarding the subcutaneous application of vedolizumab. This work supplements a position paper on the value of vedolizumab as a first-line biologic that has already been published and offers useful recommendations for clinical practice.

Schlüsselwörter

Chronisch entzündliche Darmerkrankung - Colitis ulcerosa - Morbus Crohn

Keywords

Inflammatory Bowel Disease - Ulcerative Colitis - Crohn's Disease


Publication History

Received: 30 April 2023

Accepted after revision: 03 August 2023

Article published online:
20 September 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
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