Conjugate Addition of Organoboron Compounds to α,β-Unsaturated Ketones Catalyzed by Nickelacycles

Kazuhiko Semba; Kotaro Nagase; Yoshiaki Nakao

doi:10.1055/a-2150-2912

Synlett, Table of Contents

Synlett 2023; 34(18): 2227-2231
DOI: 10.1055/a-2150-2912

cluster

Modern Boron Chemistry: 60 Years of the Matteson Reaction

Conjugate Addition of Organoboron Compounds to α,β-Unsaturated Ketones Catalyzed by Nickelacycles

Kazuhiko Semba∗

,

Kotaro Nagase

,

Yoshiaki Nakao∗

Abstract

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Abstract

The catalytic activity of nickelacycles in the conjugate addition of arylboronates to α,β-unsaturated ketones was investigated. Nickelacycles afforded β-arylated ketones in moderate to high yields, whereas an analogous palladacycle did not catalyze the reaction. Studies on the time course of the reaction confirmed that the nickelacycles act as active species in the conjugate addition reaction.

Key words

nickelacycles - nickel catalysis - organoboron compounds - enones - conjugate addition

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References

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Supplementary Material

Supporting Information